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Potentiating Antibody-Dependent Cell-Mediated Cytotoxicity via Tumor-Specific Anchoring and Activation of Nano-Haptens 期刊论文

编号：

437411A8BA0004700210078C0E2FF30D
作者：

Ye, Huan#^[1]Yan, Jing^[2];Zhou, Yang^[1];Ge, Chenglong^[1];Zhong, Ling^[3,4];Wang, Jie(汪洁)^[5]Cai, Kaimin^[6];Cheng, Jianjun^[7];Zhou, Zhuchao*^[5]Yin, Lichen*^[1]
语种：

英文
期刊：

ADVANCED MATERIALS ISSN：0935-9648 2026 年 ; 2026 MAR 12
收录：
关键词：

antibody-dependent cell-mediated cytotoxicity (ADCC) conformation-transformable polypeptide metabolic glycoengineering nano-hapten tumor immunotherapy
摘要：

Tumor-surface antigen deficiency and immunosuppressive tumor microenvironment (TME) hurdle the efficacy of antibody-dependent cellular cytotoxicity (ADCC) mediated by natural killer (NK) cells. Here, acid-activatable, polypeptide-based nano-haptens are developed and coupled with glycometabolism-mediated tumor labeling to potentiate NK cell-mediated ADCC. The nano-haptens comprise chemotactic peptide (WKYMVm)-encapsulated hollow mesoporous silica nanoparticles (HMSNs) that are shelled by conformation-transformable polypeptides containing conjugated dibenzocyclooctyne (DBCO) and dinitrophenyl derivative (FDNB) at the backbone termini. In tumor-bearing mice, an unnatural sugar (DCL-AAM) was used to glycometabolically label tumor cell surfaces with azido groups, followed by systemic administration of the nano-haptens. During blood circulation, the negatively charged, random-coiled polypeptides flatly stack on the HMSN surface, preventing WKYMVm leakage and shielding the FDNB and DBCO domains. Inside the acidic TME, the polypeptides transform into positively charged, rigid alpha-helices, unmasking the pores and releasing WKYMVm to enhance intratumoral infiltration of NK cells. Concurrently, DBCO and FDNB are conditionally exposed to enable anchoring of nano-haptens onto azido-labeled tumor cells and binding of endogenous anti-dinitrophenyl, respectively, thereby bridging tumor cells and NK cells to assist robust ADCC. When further coupled with anti-Ly49C that ameliorates the immunosuppressive TME, the nano-haptens achieve potent tumor elimination and induce durable adaptive immunity to prevent tumor recurrence.
推荐引用方式
GB/T 7714：

Ye Huan,Yan Jing,Zhou Yang, et al. Potentiating Antibody-Dependent Cell-Mediated Cytotoxicity via Tumor-Specific Anchoring and Activation of Nano-Haptens [J].ADVANCED MATERIALS,2026.
APA：

Ye Huan,Yan Jing,Zhou Yang,Ge Chenglong,&Yin Lichen.(2026).Potentiating Antibody-Dependent Cell-Mediated Cytotoxicity via Tumor-Specific Anchoring and Activation of Nano-Haptens .ADVANCED MATERIALS.
MLA：

Ye Huan, et al. "Potentiating Antibody-Dependent Cell-Mediated Cytotoxicity via Tumor-Specific Anchoring and Activation of Nano-Haptens" .ADVANCED MATERIALS(2026).
入库时间：

3/26/2026 9:13:06 PM
更新时间：

3/26/2026 9:13:06 PM

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